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Some kids may find that asthma inhalers make symptoms more frequent.
RODALE NEWS, EMMAUS, PA—Certain types of inhalers for asthma used by children around the world may not work well, or could actually be causing asthma attacks, according to British researchers. In their study, the researchers found that people with asthma who had a fairly common genetic feature, and who took at least one dose a day of the drug albuterol, were far more likely to experience asthma exacerbations, such as asthma attacks, shortness of breath, chest tightness, or wheezing.
THE DETAILS: The research is in press and will be published in the American Academy of Allergy, Asthma and Immunology's Journal of Allergy and Clinical Immunology. Researchers studied nearly 1,200 asthma patients, ages 3 to 22 years old. Children with a gene variant called ARG16 who used albuterol, a popular short-acting beta-2 agonist, on a daily basis faced a 30 percent higher risk of asthma attacks when compared to those without the gene type. If a participant had two copies of the gene, the risk jumped to 70 percent. This type of drug is used on demand for quick relief of asthma symptoms, and is sometimes prescribed to be taken 10 to 15 minutes prior to exercise. About 38 percent of the study group had at least a single copy of the gene, and 49 percent had a double copy. The same group of researchers had previously looked at salmeterol, a long-acting beta 2-agonist, and found a similar link between the patient's genetics and the drug's effectiveness.
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